Acetic Acid → HCID 22474239, compound

Participants

Reaction Steps

A mixture of 2-bromo-1-(4-methylbenzo[b]thiophen-2-yl)propan-1-one (0.27 g), 2-imidazolidinethione (0.1 g), acetic acid (2 ml) and ethanol (4 ml) was heated under reflux for 3 hours, then cooled to ambient temperature. The solvents were removed in vacuo and the residue was triturated with ether (2×1 ml). The resulting solid was collected by filtration, washed with ethanol (2 ml) and dried in vacuo at 60° C. for 2 hours to give 2-methyl-3-(4-methylbenzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (0.3 g) as a cream solid, m.p. 201-204° C.

Provenance & Evidence