反应详情

A mixture of 2-bromo-1-(4-chlorobenzo[b]thiophen-2-yl)butan-1-one (1.06 g), 2-imidazolidinethione (0.255 g) and ethanol (25 ml) was heated under reflux for 20 minutes. Acetic acid (12 ml) was added, the mixture was heated under reflux for 21 hours, then the solvents were removed in vacuo and the solid residue recrystallised from propan-2-ol (40 ml) to give 3-(4-chlorobenzo[b]thiophen-2-yl)-2-ethyl-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (0.72 g) as a white solid, m.p. 187-189° C.

1. temperaturewas heated
2. temperatureunder reflux for 20 minutes
3. temperaturethe mixture was heated
4. temperatureunder reflux for 21 hours
5. customthe solvents were removed in vacuo
6. customthe solid residue recrystallised from propan-2-ol (40 ml)