Bromine → HCID 22473769, compound

HRID 2183653Notes

Reaction equation

HRID 2183653 reaction equation
[Br:1]Br.[S:3]1[CH:7]=[CH:6][C:5]2[C:8]([C:12]3[N:13]4[CH2:19][CH2:18][N:17]=[C:14]4[S:15][CH:16]=3)=[CH:9][CH:10]=[CH:11][C:4]1=2>ClCCl>[BrH:1].[S:3]1[CH:7]=[CH:6][C:5]2[C:8]([C:12]3[N:13]4[CH2:19][CH2:18][N:17]=[C:14]4[S:15][C:16]=3[Br:1])=[CH:9][CH:10]=[CH:11][C:4]1=2

Participants

4

Reactant 2

HCID 24408BromineHCID 22473634HCID 22473634, compound

Product 1

HCID 22473769HCID 22473769, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of bromine (0.30 ml) in dichloromethane (15 ml) was added dropwise under nitrogen at 0-5° C. to a stirred solution of 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[-2,1-b]thiazole (1.45 g) in dichloromethane (40 ml), then the mixture was stirred at ambient temperature for 1 hour. The resulting solid was collected by filtration, washed with dichloromethane (20 ml) and dried in vacuo at 40-50° C. to give 3-(benzo[b]thiophen-4-yl)-2-bromo-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (2.3 g) as a pale yellow solid, m.p. 229-235° C.

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with dichloromethane (20 ml)
  3. customdried in vacuo at 40-50° C.

Sources & evidence

ORD record
ord-19fff50987224364820fa9622b7f93a4
Source dataset
uspto-grants-2005_05
Patent number
US06900216B2

Reaction notes

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