Ethanol → HCID 10159221, compound

Participants

Reaction Steps

A mixture of 2-bromo-1-(4,5-dichlorobenzo[b]thiophen-2-yl)propan-1-one (1.59 g), 2-imidazolidinethione (0.43 g), ethanol (25 ml) and acetic acid (12.5 ml) was heated under reflux for 4 hours and allowed to cool to ambient temperature. The solvent was removed in vacuo to give a yellow solid which was triturated with ether (3×10 ml). The resulting solid was collected by filtration and dried in vacuo at 60° C. to give 3-(4,5-dichlorobenzo[b]thiophen-2-yl)-2-methyl-5,6-dihydroimidazo[2,1-b]-thiazole hydrobromide (1.8 g) as a yellow solid, m.p. 244-246° C.

Provenance & Evidence