Bromine → HCID 22474068, compound

HRID 2183668Notes

Reaction equation

HRID 2183668 reaction equation
[Br:1]Br.[S:3]1[CH:7]=[CH:6][C:5]2[CH:8]=[C:9]([C:12]3[N:13]4[CH2:19][CH2:18][N:17]=[C:14]4[S:15][CH:16]=3)[CH:10]=[CH:11][C:4]1=2>ClCCl>[BrH:1].[S:3]1[CH:7]=[CH:6][C:5]2[CH:8]=[C:9]([C:12]3[N:13]4[CH2:19][CH2:18][N:17]=[C:14]4[S:15][C:16]=3[Br:1])[CH:10]=[CH:11][C:4]1=2

Participants

4

Reactant 2

HCID 24408BromineHCID 22473608HCID 22473608, compound

Product 1

HCID 22474068HCID 22474068, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of bromine (0.4 ml) in dichloromethane (5 ml) was added dropwise under nitrogen to a stirred suspension of 3-(benzo[b]thiophen-5-yl)-5,6-dihydroimidazo[2,1-b]thiazole (1.9 g) in dichloromethane (20 ml), then the mixture was stirred at ambient temperature for 30 minutes. The resulting solid was collected by filtration and dried in vacuo at ambient temperature to give 3-(benzo[b]thiophen-5-yl)-2-bromo-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (1.9 g) as a yellow solid which was used without further purification. Concentration of the filtrate yielded a second crop of 3-(benzo[b]thiophen-5-yl)-2-bromo-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (0.4 g) as a yellow solid.

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. customdried in vacuo at ambient temperature

Sources & evidence

ORD record
ord-8e850a9ad36a45a0a1d3f1fc129c83b2
Source dataset
uspto-grants-2005_05
Patent number
US06900216B2

Reaction notes

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