Fumaric Acid → HCID 22474038, compound

Participants

Reaction Steps

A mixture of 3-(benzo[b]thiophen-4-yl)-2-(methylthio)-5,6-dihydroimidazo[2,1-b]thiazole (5.5 g), fumaric acid (2.1 g) and methanol (32 ml) was heated under reflux for 5 minutes then stirred at ambient temperature for 25 minutes. The resulting solid was collected by filtration, washed with ice-cold methanol (10 ml) and dried in vacuo at 95° C. for 2.5 hours to give 3-(benzo[b]thiophen-4-yl)-2-(methylthio)-5,6-dihydroimidazo[2,1-b]thiazole fumarate (6.4 g) as a colourless solid, m.p. 185-187° C.

Provenance & Evidence