Phenylboronic Acid → HCID 86585105, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 43 mg (0.13 mmol) 7-Iodo-2-methyl-4-pyrrolidin-1-yl-quinoline in 1.2 ml dioxane/dimethoxyethane 1:1 was added 39.6 mg (0.325 mmol) phenyl-boronic acid, 6 mg (0.007 mmol) Dichloro[1,1′-Bis(diphenylphosphino)-ferrocene]palladium (II) dichloromethan adduct, and 0.55 ml 2M Na2CO3aq. and the mixture was heated to 85° C. for 12 h. After filtration the mixture was purified by reversed phase column chromatography eluting with an acetonitrile/water (formic acid) gradient yielding 25 mg (57%) of the title compound. MS m/e (%): 289.4 (MH+, 100).

Provenance & Evidence