N,N-Dimethylaniline → HCID 10480845, compound

Participants

Reaction Conditions

Reaction Steps

2-{6-[1-(4-Cyano-phenyl)-1H-indazol-5-yloxy]-pyridin-3-ylamino}-malonic acid diethyl ester can be prepared by combining 4-[5-(5-Amino-pyridin-2-yloxy)-indazol-1-yl]-benzonitrile (11.4 mmol), bromodiethylmalonate (11.4 mmol), and N,N-dimethylaniline (11.4 mmol) in a flame dried flask and heated to 70° C. for 3.5 hours. The mixture is cooled to room temperature, adsorbed to silica gel and chromatographed (gradient elution, ethyl acetate-hexanes) to afford the title compound.

Provenance & Evidence