反应详情

A solution of NaNO2 (9.59 g, 139 mmol) in water (95 mL) was added slowly to a solution of commercially available (Oakwood) 2,6-dichloro-4-(trifluoromethyl)nicotinamide (20.0 g, 77 mmol) in conc. H2SO4 resulting in evolution of heat and brown gas. The mixture was stirred at room temperature for 15 min, and then heated to 60° C. for 18 h. The solution was cooled to 0° C. and then water (15 mL) was added. The resulting mixture was extracted with Et2O (3×) and the combined organic extracts were dried over MgSO4 and concentrated in vacuo. The residue was triturated with hexanes and vacuum-filtered to afford 2,6-dichloro-4-(trifluoromethyl)nicotinic acid (19 g, 95%) as an off-white solid: Rf=0.30 (9:1 CH2Cl2:MeOH), 1H-NMR (d6-DMSO, 300 MHz) δ 8.18 (s, 1H).

1. temperatureof heat
2. temperatureheated to 60° C. for 18 h
3. temperatureThe solution was cooled to 0° C.
4. extractionThe resulting mixture was extracted with Et2O (3×)
5. dry with materialthe combined organic extracts were dried over MgSO4
6. concentrationconcentrated in vacuo
7. customThe residue was triturated with hexanes
8. filtrationvacuum-filtered