4-Chloro-2-fluorobenzonitrile → HCID 90887959, compound

HRID 2183841Notes

Reaction equation

HRID 2183841 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4](F)[CH:3]=1.[CH:11]1([CH:14]([OH:26])[CH2:15][CH2:16][N:17]([CH3:25])[C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:13][CH2:12]1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH:3]=1)[O:26][CH:14]([CH:11]1[CH2:12][CH2:13]1)[CH2:15][CH2:16][N:17]([CH3:25])[C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 936554-Chloro-2-fluorobenzonitrileHCID 86587541HCID 86587541, compound

Product 1

HCID 90887959HCID 90887959, compound

Procedure

The title compound was prepared according to the method of Example 3 step (b) but using 4-chloro-2-fluorobenzonitrile and (3-cyclopropyl-3-hydroxypropyl)methylcarbamic acid, 1,1-dimethylethyl ester.

Sources & evidence

ORD record
ord-5c2bf95b09e5464cbd255cb1f00aa283
Source dataset
uspto-grants-2005_05
Patent number
US06900243B2

Reaction notes

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