HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorotrimethylsilane → 307316-20-7
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 4-Amino-2-hydroxybutyric acid, (S)-(-)- | HCID 2733929 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 307316-20-7 | HCID 86596723 | 100% |
Reaction Steps
(S)-(−)-4-Amino-2-hydroxybutyric acid (5.432 g, 45.6 mmol) was dissolved in methanol (250 ml) and chlorotrimethylsilane (4.86 g, 137 mmol) added. The reaction was gently refluxed for 20 h. The reaction was cooled and the solvent removed in vacuo to afford the title compound as a colourless oil (6.07 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900243B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-0011235d853344b7a317c13792f645f1 |
| Source note | uspto-grants-2005_05 |