Triphenylphosphine → HCID 69743753, compound

Participants

Reaction Conditions

Reaction Steps

The product of step (b) (3.25 g, 13.9 mmol), 4-chloro-2-hydroxybenzonitrile (2.14 g, 13.9 mmol) and triphenylphosphine (4.38 g, 16.7 mmol) were dissolved in anhydrous tetrahydrofuran (80 ml) and the solution cooled to 0° C. Diethyl azodicarboxylate (2.91 g, 16.7 mmol) was added dropwise and the solution allowed to warm to room temperature, then stirred for 2 days. The solvent was removed in vacuo and the residue chromatographed on flash silica, eluting with hexane:ethyl acetate (3:1), to afford the title compound as a white solid (3.562 g, 69%).

Provenance & Evidence