2′-Fluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile → 5'-[7-(1,1-Dimethoxyethyl)imidazo[1,2-alpha]pyrimidin-3-yl]-2'-fluorobiphenyl-2-carbonitrile

Participants

Reaction Steps

3-Bromo-7-(1,1-dimethoxyethyl)imidazo[1,2-α]pyrimidine (860 mg, 3 mmol) was coupled with 2′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile (1.45 g, 4.5 mmol) as described in Example 1 to give crude 5′-[7-(1,1-dimethoxyethyl)imidazo[1,2-α]pyrimidin-3-yl]-2′-fluorobiphenyl-2-carbonitrile (1.21 g).

Provenance & Evidence