2′-Fluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile → 2'-Fluoro-5'-[7-(1-fluoro-1-methylethyl)imidazo[1,2-alpha]pyrimidin-3-yl]biphenyl-2-carbonitrile

Participants

Reaction Steps

3-Bromo-7-(1-fluoro-1-methylethyl)imidazo[1,2-α]pyrimidine was coupled with 2′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile in the same way as described for Example 1 to give 2′-fluoro-5′-[7-(1-fluoro-1-methylethyl)imidazo[1,2-α]pyrimidin-3-yl]biphenyl-2-carbonitrile as an off-white solid: δH (360 MHz, DMSO) 1.76 (6H, d, J 22), 7.27 (1H, dd, J 6 and 1), 7.64-7.72 (2H, m), 7.80 (1H, s), 7.89-7.92 (3H, m), 8.04 (1H, s), 8.06 (1H, s), 9.15 (1H, d, J 7); m/z (ES+) 375 (M++H).

Provenance & Evidence