2′-Fluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile → HCID 10199642, compound

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Reaction Steps

3-Bromo-7-(1,1-difluoroethyl)imidazo[1,2-α]pyrimidine (130 mg, 0.50 mmol) was coupled with 2′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 5′-[7-(1,1-difluoroethyl)imidazo[1,2-α]pyrimidin-3-yl]-2′-fluorobiphenyl-2-carbonitrile (45 mg, 24%) as a white powder: δH (400 MHz, CDCl3) 2.15 (3H, t, J 21), 7.34 (1H, d, J 7), 7.43 (1H, t, J 9), 7.53-7.74 (5H, m), 7.86 (1H, dd, J 8 and 1), 7.99 (1H, s), 8.95 (1H, d, J 7); m/z (ES+) 379 (M++H).

Provenance & Evidence