2′-Fluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile → HCID 9924945, compound

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Reaction Steps

3-Bromo-7-methoxymethylimidazo[1,2-α]pyrimidine (121 mg, 0.50 mmol) was coupled with 2′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 2′-fluoro-5′-(7-methoxymethylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-2-carbonitrile (108 mg, 60%) as a white powder: δH (400 MHz, CDCl3) 3.50 (3H, s), 4.66 (2H, s), 7.19 (1H, d, J 7), 7.39-7.41 (1H, m), 7.53-7.64 (4H, m), 7.69-7.73 (1H, m), 7.85 (1H, dd, J 8 and 1), 7.87 (1H, s), 8.82 (1H, d, J 7); m/z (ES+) 359 (M++H).

Provenance & Evidence