2′-Fluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile → HCID 10178861, compound

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Reaction Steps

3-Bromo-7-(3-methyl-[1,2,4]oxadiazol-5-yl)imidazo[1,2-α]pyrimidine was coupled with 2′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 2 to give 2′-fluoro-5′-[7-(3-methyl-[1,2,4]oxadiazol-5-yl)imidazo[1,2-α]pyrimidin-3-yl]biphenyl-2-carbonitrile as a yellow solid: δH (400 MHz, CDCl3) 2.55 (3H, s), 7.46 (1H, t, J 9), 7.56-7.59 (1H, m), 7.64 (2H, dd, J 7 and 2), 7.69-7.73 (2H, m), 7.81-7.87 (2H, m), 8.16 (1H, s), 9.05 (1H, s); m/z (ES+) 397 (M++H).

Provenance & Evidence