3-Bromo-7-difluoromethylimidazo[1,2-a]pyrimidine → 3'-(7-Difluoromethylimidazo[1,2-alpha]pyrimidin-3-yl)-4'-fluorobiphenyl-2-carbonitrile

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Reaction Steps

3-Bromo-7-difluoromethylimidazo[1,2-α]pyrimidine (124 mg, 0.50 mmol) was coupled with 4′-fluoro-3′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 3′-(7-difluoromethylimidazo[1,2-α]pyrimidin-3-yl)-4′-fluorobiphenyl-2-carbonitrile (180 mg, 49%) as a yellow powder: δH (400 MHz, CDCl3) 6.69 (1H, t, J 55), 7.32 (1H, d, J 7), 7.42-7.57 (3H, m), 7.64-7.76 (3H, m), 7.84 (1H, dd, J 8 and 1), 8.13 (1H, d, J 1), 8.79 (1H, dd, J 7 and 2); m/z (ES+) 365 (M++H).

Provenance & Evidence