Thiophene-3-boronic acid → HCID 10222374, compound

Participants

Reaction Steps

5′-(7-Chloroimidazo[1,2-α]pyrimidin-3-yl)-2′-fluorobiphenyl-2-carbonitrile (50 mg, 0.143 mmol) and 3-thiopheneboronic acid (346 mg, 0.287 mmol) were reacted using the procedure in Example 23 to give 2′-fluoro-5′-[7-(thien-3-yl)imidazo[1,2-α]pyrimidin-3-yl]biphenyl-2-carbonitrile (44 mg, 77%) as a yellow powder: δH (400 MHz, CDCl3) 7.31 (1H, d, J 7), 7.39-7.45 (2H, m), 7.55 (1H, dt, J 9 and 1), 7.61-7.67 (3, m), 7.71 (1H, dt, J 8 and 1), 7.84-7.90 (3H, m), 8.11 (1H, s), 8.82 (1H, d, J 7); m/z (ES+) 397 (M++H).

Provenance & Evidence