2′-Fluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile → HCID 9968066, compound

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Reaction Steps

3-Bromo-6-fluoro-7-methylimidazo[1,2-α]pyrimidine (24 mg, 0.50 mmol) was coupled with 2′-fluoro-5′-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 2′-fluoro-5′-(6-fluoro-7-methylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-2-carbonitrile (21 mg, 58%) as a white powder: δH (400 MHz, CDCl3) 2.67 (3H, d, J 3), 7.39-7.43 (1H, m), 7.53-7.62 (4H, m), 7.69-7.74 (1H, m), 7.84 (1H, d, J 1), 7.86 (1H, s), 8.67 (1H, d, J 5); m/z (ES+) 347 (M++H).

Provenance & Evidence