3'-Fluoro-5'-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile → 3'-Fluoro-5'-(7-hydroxymethylimidazo[1,2-alpha]pyrimidin-3-yl)biphenyl-2-carbonitrile

Participants

Reaction Steps

3-Bromoimidazo[1,2-α]pyrimidin-7-ylmethanol was coupled with 3′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile as described in Example 1 to give 3′-fluoro-5′-(7-hydroxymethylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-2-carbonitrile as a yellow solid: δH (360 MHz, DMSO) 4.71 (2H, d, J 6), 5.81 (1H, t, J 6), 7.31 (1H, d, J 7), 7.63 (1H, d, J 9), 7.74-7.95 (5H, m), 8.10 (1H, d, J 8), 8.14 (1H, s), 9.26 (1H, d, J 7); m/z (ES+) 345 (M++H).

Provenance & Evidence