3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → 2-Fluoro-3-(7-trifluoromethylimidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile

Participants

Reaction Steps

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 2′-cyano-2-fluorobiphenyl-3-boronic acid as described in Example 1 to give 2′-fluoro-3′-(7-trifluoromethylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-2-carbonitrile as an off-white solid (70 mg, 18%): δH (400 MHz, DMSO) 7.60-7.64 (2H, m), 7.70 (1H, d, J 1), 7.76 (1H, d, J 2), 7.83 (1H, s), 7.87-7.91 (2H, m), 8.05 (1H, dd, J 7 and 1), 8.35 (1H, s), 9.13 (1H, dd, J 7 and 3); m/z (ES+) 383 (M++H).

Provenance & Evidence