Imidazole → HCID 10222227, compound

Participants

Reaction Steps

5′-(7-Bromomethylimidazo[1,2-α]pyrimidin-3-yl)-2′-fluorobiphenyl-2-carbonitrile was reacted with the sodium salt of imidazole as described in Example 34 to give 2′-fluoro-5′-[7-(imidazol-1-ylmethyl)imidazo[1,2-α]pyrimidin-3-yl]biphenyl-2-carbonitrile: δH (360 MHz, CDCl3) 5.33 (2H, s), 6.62 (1H, d, J 7), 7.05 (1H, s), 7.15 (1H, s), 7.38-7.43 (1H, m), 7.52-7.73 (6H, m), 7.83 (1H, d, J 7), 7.92 (1H, s), 8.80 (1H, s); m/z (ES+) 395 (M++H).

Provenance & Evidence