3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → 3-[2,4-Difluoro-3-(pyridin-3-yl)phenyl]-7-trifluoromethylimidazo[1,2-alpha]pyrimidine

Participants

Reaction Steps

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 2,4-difluoro-3-(pyridin-3-yl)benzeneboronic acid as described in Example 1 to give 3-[2,4-difluoro-3-(pyridin-3-yl)phenyl]-7-trifluoromethylimidazo[1,2-α]pyrimidine as an off-white solid. Bis-hydrochloride salt (from ethyl acetate/ethanol): δH (400 MHz, DMSO) 7.60-7.65 (2H, m), 7.90-7.96 (2H, m), 8.34 (1H, s), 8.47 (1H, d, J 8), 8.87 (1H, dd, J 5 and 1), 9.08 (1H, s), 9.32 (1H, dd, J 7 and 3).

Provenance & Evidence