3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → 3-[2-Fluoro-3-(pyridin-4-yl)phenyl]-7-trifluoromethylimidazo[1,2-alpha]pyrimidine

Participants

Reaction Steps

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 2-fluoro-3-(pyridin-4-yl)benzeneboronic acid as described in Example 1 to give 3-[2-fluoro-3-(pyridin-4-yl)phenyl]-7-trifluoromethylimidazo[1,2-α]pyrimidine as a white solid. Bis-hydrochloride salt (from ethyl acetate/ethanol): δH (400 MHz, DMSO) 7.64-7.70 (2H, m), 7.95-8.01 (2H, m), 8.37 (1H, s), 8.39 (2H, s), 9.05-9.07 (2H, m), 9.40 (1H, dd, J 7 and 3); m/z (ES+) 359 (M++H).

Provenance & Evidence