HCID 22473557, compound → HCID 22473541, compound

Participants

Reaction Steps

To a solution of 2-(2-fluoro-5-nitrophenyl)-4-methylpyridine (0.6 g, 2.6 mmol) in ethanol (50 ml) was added platinum(IV) oxide (100 mg) and the mixture stirred for 35 min under hydrogen (40 psi). The catalyst was filtered off and the solution evaporated to dryness to give 4-fluoro-3-(4-methylpyridin-2-yl)phenylamine as a brown oil: δH (400 MHz, CDCl3) 8.55 (1H, d, J 5), 7.59-7.62 (1H, m), 7.27 (1H, dd, J 6 and 3), 7.06-7.09 (1H, m), 6.95 (1H, dd, J 11 and 9), 6.64-6.68 (1H, m), 2.60-3.20 (2H, br), 2.41 (3H, s); m/z (ES+) 203 (M++H).

Provenance & Evidence