Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)- → HCID 69708303, compound

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Reaction Steps

2-(5-Bromo-2-fluorophenyl)-4-methylpyridine was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine by the method of Example 32. Purification by chromatography on silica gel eluting with dichloromethane containing 1% methanol, then crystallisation from ethyl acetate/isohexane, gave 3-[4-fluoro-3-(4-methylpyridin-2-yl)phenyl]-7-trifluoromethylimidazo[1,2-α]pyrimidine as a yellow powder: δH (400 MHz, CDCl3) 8.87 (1H, d, J 7), 8.58 (1H, d, J 5), 8.24 (1H, dd, J 7 and 2), 8.12 (1H, s), 7.71 (1H, s), 7.53-7.58 (1H, m), 7.38 (1H, dd, J 11 and 8), 7.26 (1H, d, J 7), 7.16 (1H, d, J 5), 2.46 (3H, s); m/z (ES+) 373 (M++H).

Provenance & Evidence