3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → 3,2-Difluoro-5-(7-trifluoromethylimidazo[1,2-a]pyrimidin-3-yl)biphenyl-2-carbonitrile

Participants

Reaction Steps

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 5′-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-3,2′-difluorobiphenyl-2-carbonitrile as described in Example 1 to give 3,2′-difluoro-5′-(7-trifluoromethylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-2-carbonitrile as an off-white solid: δH (360 MHz, CDCl3) 7.31 (2H, dd, J 7 and 3), 7.43-7.49 (2H, m), 7.64-7.75 (3H, m), 8.10 (1H, s), 9.04 (1H, d, J 7); m/z (ES+) 401 (M++H).

Provenance & Evidence