HCID 11336372, compound → HCID 9843909, compound

HRID 2183970Notes

Reaction equation

HRID 2183970 reaction equation
Br[C:2]1[N:6]2[CH:7]=[CH:8][C:9]([C:11]([F:14])([F:13])[F:12])=[N:10][C:5]2=[N:4][CH:3]=1.CC1(C)COB([C:22]2[CH:23]=[CH:24][C:25]([F:37])=[C:26]([C:28]3[C:29]([C:35]#[N:36])=[CH:30][C:31]([F:34])=[CH:32][CH:33]=3)[CH:27]=2)OC1>>[F:34][C:31]1[CH:30]=[C:29]([C:35]#[N:36])[C:28]([C:26]2[CH:27]=[C:22]([C:2]3[N:6]4[CH:7]=[CH:8][C:9]([C:11]([F:14])([F:13])[F:12])=[N:10][C:5]4=[N:4][CH:3]=3)[CH:23]=[CH:24][C:25]=2[F:37])=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 11336372HCID 11336372, compoundHCID 113914623-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine

Product 1

HCID 9843909HCID 9843909, compound

Procedure

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 5′-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-4,2′-difluorobiphenyl-2-carbonitrile as described in Example 1 to give 4,2′-difluoro-5′-(7-trifluoromethylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-2-carbonitrile as an off-white solid: δH (400 MHz, CDCl3) 7.29 (1H, d, J 7), 7.42-7.48 (2H, m), 7.57 (1H, dd, J 8 and 3), 7.61-7.66 (3H, m), 8.10 (1H, s), 9.02 (1H, d, J 7); m/z (ES+) 401 (M++H).

Sources & evidence

ORD record
ord-139d336bad5f4b248c0e8b4c4e862779
Source dataset
uspto-grants-2005_05
Patent number
US06900215B2

Reaction notes

Loading…