Trimethyl borate → HCID 22473587, compound

HRID 2183972Notes

Reaction equation

HRID 2183972 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[C:10]([C:15]#[N:16])=[CH:11][CH:12]=[CH:13][CH:14]=1.[B:17](OC)([O:20]C)[O:18]C>>[C:15]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[C:3]1[C:2]([F:1])=[CH:7][CH:6]=[C:5]([B:17]([OH:20])[OH:18])[C:4]=1[F:8])#[N:16]

Participants

3

Reactant 2

HCID 8470Trimethyl borateHCID 22473553HCID 22473553, compound

Product 1

HCID 22473587HCID 22473587, compound

Procedure

2′,6′-Difluorobiphenyl-2-carbonitrile was lithiated and reacted with trimethyl borate as described in Example 31 to give 2′-cyano-2,6-difluorobiphenyl-3-boronic acid as a white crystalline solid.

Sources & evidence

ORD record
ord-acab3acab28946b4ab4f3fa7061c8118
Source dataset
uspto-grants-2005_05
Patent number
US06900215B2

Reaction notes

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