Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)- → HCID 10109084, compound

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Reaction Steps

2-(5-Bromo-2-fluorophenyl)pyrazine was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine by the method of Example 32. Purification by chromatography on silica gel eluting with dichloromethane containing 4% methanol followed by crystallisation from hot toluene gave 3-[4-fluoro-3-(pyrazin-2-yl)phenyl]-7-trifluoromethylimidazo[1,2-α]pyrimidine: δH (400 MHz, DMSO) 9.31 (1H, d, J 7), 9.14 (1H, m), 8.85 (1H, dd, J 2 and 1.5), 8.73 (1H, d, J 2), 8.32 (1H, s), 8.27 (1H, dd, J 7 and 2), 7.96 (1H, m), 7.68 (1H, dd, J 11 and 9), 7.54 (1H, d, J 7); m/z (ES+) 360 (M++H).

Provenance & Evidence