3-(3-Bromo-2,6-difluorophenyl)pyridine → 7-(1,1-Difluoroethyl)-3-[2,4-difluoro-3-(pyridin-3-yl)phenyl]imidazo[1,2-alpha]pyrimidine

Participants

Reaction Steps

7-(1,1-Difluoroethyl)-3-tributylstannylimidazo[1,2-α]pyrimidine was reacted with 3-(3-bromo-2,6-difluorophenyl)pyridine following the procedure described in Example 32 to give 7-(1,1-difluoroethyl)-3-[2,4-difluoro-3-(pyridin-3-yl)phenyl]imidazo[1,2-α]pyrimidine as a white solid: δH (360 MHz, CDCl3) 2.16 (1H, t, J 19), 7.22-7.78 (1H, m), 7.31 (1H, d, J 7), 7.59 (1H, ddd, J 8, 3 and 1), 7.52-7.59 (1H, m), 7.85 (1H, dd, J 8 and 1), 8.03 (1H, s), 8.39 (1H, dd, J 7 and 3), 8.69 (1H, d, J 5 and 3), 8.78 (1H, s); m/z (ES+) 373 (M++H).

Provenance & Evidence