2-(3-Bromoimidazo[1,2-a]pyrimidin-7-yl)propan-2-ol → 3'-[7-(1-Hydroxy-1-methylethyl)imidazo[1,2-alpha]pyrimidin-3-yl]-4,2',6'-trifluorobiphenyl-2-carbonitrile

Participants

Reaction Steps

2-(3-Bromoimidazo[1,2-α]pyrimidin-7-yl)propan-2-ol was coupled with 3′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-4,2′,6′-trifluorobiphenyl-2-carbonitrile as described in Example 65 to give 3′-[7-(1-hydroxy-1-methylethyl)imidazo[1,2-α]pyrimidin-3-yl]-4,2′,6′-trifluorobiphenyl-2-carbonitrile as an off-white solid: δH (400 MHz, d6-DMSO) 1.51 (6H, s), 7.42 (1H, d, J 7), 7.54-7.58 (1H, m), 7.80-7.85 (1H, m), 7.89-7.96 (3H, m), 8.14 (1H, dd, J 9 and 2), 8.78 (1H, dd, J 7 and 3).

Provenance & Evidence