2-(3-Bromoimidazo[1,2-a]pyrimidin-7-yl)propan-2-ol → HCID 10177677, compound

Participants

Reaction Steps

2-(3-Bromoimidazo[1,2-α]pyrimidin-7-yl)propan-2-ol was coupled with 3-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]thiophene-2-carbonitrile as described in Example 65 to give 3-{2-fluoro-5-[7-(1-hydroxy-1-methylethyl)imidazo[1,2-α]pyrimidin-3-yl]phenyl}thiophene-2-carbonitrile as a buff-coloured solid: δH (400 MHz, CDCl3) 1.57 (6H, s), 7.10 (1H, d, J 7), 7.41-7.44 (2H, m), 7.60-7.64 (1H, m), 7.71 (1H, d J 5), 7.84 (1H, dd, J 7 and 2), 7.87 (1H, s), 8.88 (1H, d, J 7).

Provenance & Evidence