3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → HCID 10292903, compound

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Reaction Steps

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled to 4-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]-3-fluoropyridine using the method of Example 65 to give 3-[4-fluoro-3-(3-fluoropyridin-4-yl)phenyl]-7-trifluoromethylimidazo[1,2-α]pyrimidine as a yellow solid (130 mg, 35%): δH (400 MHz, CDCl3) 7.28 (1H, d, J 7), 7.43-7.48 (2H, m), 7.63-7.68 (2H, m), 8.11 (1H, s), 8.55 (1H, d, J 5), 8.64 (1H, d, J 1), 8.77 (1H, d, J 7).

Provenance & Evidence