3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → HCID 10223673, compound

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Reaction Steps

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 4-chloro-2′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile by the method of Example 65 to give 4-chloro-2′-fluoro-5′-(7-trifluoromethylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-2-carbonitrile as an off-white solid: δH (360 MHz, CDCl3) 7.29 (1H, d, J 7), 7.43-7.48 (1H, t, J 9), 7.54-7.71 (4H, m), 7.83 (1H, d, J 2), 8.10 (1H, s), 9.02 (1H, d, J 7).

Provenance & Evidence