3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → HCID 10199517, compound

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Reaction Steps

4-Fluoro-3-(3-fluoropyridin-2-yl)phenylboronic acid was coupled with 3-bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine by the method of Example 78. Purification by chromatography on silica gel eluting with dichloromethane containing 3.5% methanol and crystallisation from methanol gave 3-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-7-trifluoromethylimidazo[1,2-α]pyrimidine: δH (400 MHz, DMSO) 9.28 (1H, d, J 7), 8.61 (1H, m), 8.31 (1H, s), 7.90-7.99 (3H, m), 7.62 (2H, m), 7.52 (1H, d, J 7); m/z (ES+) 377 (MH+).

Provenance & Evidence