HCID 10199517, compound → HCID 10270246, compound

Participants

Reaction Steps

4-Fluoro-3-(3-fluoropyridin-2-yl)phenylboronic acid (prepared according to Example 80) was coupled with 2-(3-bromoimidazo[1,2-α]pyrimidin-7-yl)propan-2-ol by the method of Example 78. Purification by chromatography on silica gel, eluting with dichloromethane containing 3.5% methanol, gave 2-[3-(4-fluoro-3-(3-fluoropyridin-2-yl)phenyl)imidazo[1,2-α]pyrimidin-7-yl]propan-2-ol which was converted to its hydrochloride salt by treatment with methanolic hydrogen chloride, evaporation, and crystallisation of the residue from isopropanol/ethyl acetate: δH (400 MHz, DMSO) 1.56 (6H, s), 7.62-7.71 (1H, m), 7.70 (1H, dd, J 9 and 2), 7.87 (1H, d, J 7.4), 7.92-8.00 (3H, m), 8.54 (1H, s), 8.61 (1H, m), 9.25 (1H, d, J 7); m/z (ES+) 367 (MH+).

Provenance & Evidence