反应详情

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 2,4-difluoro-3-(pyridin-4-yl)benzeneboronic acid as described in Example 65 to give 3-[2,4-difluoro-3-(pyridin-4-yl)phenyl]-7-trifluoromethylimidazo[1,2-α]pyrimidine as a white solid. Bis-hydrochloride (from ethanol/ethyl acetate): δH (400 MHz, DMSO) 7.60-7.65 (2H, m), 7.96-8.01 (1H, m), 8.16 (2H, d, J 6), 8.34 (1H, s), 9.00-9.02 (2H, m), 9.34 (1H, dd, J 7 and 3); m/z (ES+) 377 (M++H).