反应详情

2-(3-Bromoimidazo[1,2-α]pyrimidin-7-yl)propan-2-ol was coupled with 2,4-difluoro-3-(pyridin-4-yl)benzeneboronic acid as described in Example 65 to give 2-[3-(2,4-difluoro-3-(pyridin-4-yl)phenyl)imidazo[1,2-α]pyrimidin-7-yl]propan-2-ol as an off-white solid. Bis-hydrochloride (from ethanol/ethyl acetate): δH (360 MHz, DMSO) 1.56 (6H, s), 7.62-7.67 (1H, m), 7.85 (1H, d, J 7), 7.88-7.94 (1H, m), 7.99 (2H, d, J 6), 8.50 (1H, s), 8.94 (2H, d, J 6), 9.26 (1H, dd, J 7 and 3); m/z (ES+) 367 (M++H).