2-(3-Bromoimidazo[1,2-a]pyrimidin-7-yl)propan-2-ol → HCID 69707810, compound

Participants

Reaction Steps

2-(3-Bromoimidazo[1,2-α]pyrimidin-7-yl)propan-2-ol was coupled with 5′-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-4,2′-difluorobiphenyl-2-carbonitrile as described in Example 65 to give 4,2′-difluoro-5-[7-(1-hydroxy-1-methylethyl)imidazo[1,2-α]pyrimidin-3-yl]biphenyl-2-carbonitrile as a white solid: δH (400 MHz, CDCl3) 1.62 (6H, s), 4.47 (1H, s), 7.08 (1H, d, J 7), 7.39-7.46 (2H, m), 7.55 (1H, dd, J 8 and 3), 7.60-7.64 (3H, m), 7.85 (1H, s), 8.81 (1H, d, J 7); m/z (ES+) 391 (M++H).

Provenance & Evidence