3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → HCID 10177917, compound

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Reaction Steps

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 5′-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-2′-fluorobiphenyl-3-carbonitrile as described in Example 65 to give 2′-fluoro-5′-(7-trifluoromethylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-3-carbonitrile as a yellow solid: δH (360 MHz, CDCl3) 7.28 (1H, d, J 7), 7.40-7.46 (1H, m), 7.55-7.64 (3H, m), 7.72-7.75 (1H, m), 7.83 (1H, dd, J 7 and 1), 7.89 (1H, d, J 1), 8.11 (1H, s), 8.75 (1H, d, J 7); m/z (ES+) 383 (M++H).

Provenance & Evidence