3-bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → 2'-Fluoro-5'-(7-trifluoromethylimidazo[1,2-alpha]pyrimidin-3-yl)biphenyl-4-carbonitrile

Beteiligte Stoffe

Reaktionsschritte

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 5′-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-2′-fluorobiphenyl-4-carbonitrile as described in Example 65 to give 2′-fluoro-5′-(7-trifluoromethylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-4-carbonitrile as a yellow solid: δH (360 MHz, CDCl3) 7.26 (1H, d, J 7), 7.44 (1H, dd, J 8 and 8), 7.55-7.63 (2H, m), 7.70 (2H, dd, J 7 and 1), 7.79 (2H, dd, J 7 and 1), 8.11 (1H, s), 8.74 (1H, d, J 7); m/z (ES+) 383 (M++H).

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