3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine → HCID 69708908, compound

Participants

Reaction Steps

3-Bromo-7-trifluoromethylimidazo[1,2-α]pyrimidine was coupled with 3′-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-4-fluoro-2′-methylbiphenyl-2-carbonitrile as described in Example 65 to give 4-fluoro-2′-methyl-3′-(7-trifluoromethylimidazo[1,2-α]pyrimidin-3-yl)biphenyl-2-carbonitrile as a white solid: δH (360 MHz, CDCl3) 1.94 (3H, s), 7.26 (1H, d, J 7), 7.40-7.51 (6H, m), 8.08 (1H, s), 8.35 (1H, d, J 7); m/z (ES+) 397 (M++H).

Provenance & Evidence