4-Fluoro-3-(pyridin-3-yl)benzeneboronic acid → 2-[3-(4-Fluoro-3-(pyridin-3-yl)phenyl)imidazo[1,2-alpha]pyrimidin-7-yl)-2-methylpropionitrile

Participants

Reaction Steps

2-(3-Bromoimidazo[1,2-α]pyrimidin-7-yl)-2-methylpropionitrile and 4-fluoro-3-(pyridin-3-yl)benzeneboronic acid were coupled following the procedure in Example 65 to give 2-[3-(4-fluoro-3-(pyridin-3-yl)phenyl)imidazo[1,2-α]pyrimidin-7-yl)-2-methylpropionitrile as a white solid: δH (360 MHz, CDCl3) 1.86 (6H, s), 7.32 (1H, d, J 7), 7.38-7.45 (2H, m), 7.53-7.62 (2H, m), 7.86-7.97 (1H, m), 7.91 (1H, d, J 3), 8.62 (1H, d, J 7), 8.67 (1H, dd, J 8 and 3), 8.84 (1H, s); m/z (ES+) 358 (M++H).

Provenance & Evidence