Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)- → HCID 69708353, compound

Participants

Reaction Steps

2-(5-Bromo-2-fluorophenyl)-6-methoxypyridine (595 mg, 2.1 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazol[1,2-α]pyrimidine (3.2 mmol) by the method of Example 32. Purification by chromatography on silica gel eluting with dichloromethane containing 1% methanol, then crystallisation from methanol, gave 3-[4-fluoro-3-(6-methoxypyridin-2-yl)phenyl]-7-trifluoromethylimidazo[1,2-α]pyrimidine as a yellow solid: δH (400 MHz, CDCl3) 3.98 (3H, s), 6.79 (1H, d, J 8), 7.26 (1H, d, J 10), 7.38 (1H, dd, J 11 and 9), 7.52-7.56 (2H, m), 7.70 (1H, t, J 8), 8.12 (1H, s), 8.36 (1H, dd, J 7 and 2), 8.85 (1H, d, J 7).

Provenance & Evidence