Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)- → HCID 69708694, compound

Participants

Reaction Steps

2-(5-Bromo-2-fluorophenyl)-4-methoxypyridine (50 mg, 0.2 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (0.3 mmol) by the method of Example 32. Purification by chromatography on silica gel eluting with dichloromethane containing 1% methanol gave 3-[4-fluoro-3-(4-methoxypyridin-2-yl)phenyl]-7-trifluoromethylimidazo[1,2-α]pyrimidine as a yellow solid: δH (400 MHz, CDCl3) 3.93 (3H, s), 6.86 (1H, dd, J 5 and 2), 7.26 (1H, d, J 7), 7.38 (1H, dd, J 11 and 9), 7.42 (1H, s), 7.54-7.58 (1H, m), 8.12 (1H, s), 8.26 (1H, dd, J 7 and 2), 8.54 (1H, d, J 5), 8.86 (1H, d, J 7); m/z (ES+) 388 (M++H).

Provenance & Evidence