2-Bromothiazole → HCID 22473555, compound

Participants

Reaction Steps

2-Bromothiazole (2.1 ml, 22.9 mmol) was coupled to 2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (3.0 g, 11.6 mmol) using the method in Example 47. Purification by chromatography on silica gel eluting with dichloromethane then recrystallisation from toluene/isohexane gave 2-(2-fluoro-5-nitrophenyl)thiazole as a brown solid: δH (360 MHz, CDCl3) 7.38 (1H, t, J 9), 7.58 (1H, d, J 3), 8.03 (1H, t, J 3), 8.26-8.31 (1H, m), 9.26 (1H, d, J 6 and 3).

Provenance & Evidence