Imidazo[1,2-a]pyrimidine, 3-(tributylstannyl)-7-(trifluoromethyl)- → HCID 69707978, compound

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Reaction Steps

3-(5-Bromo-2-fluorophenyl)isonicotinonitrile (40 mg, 0.14 mmol) was coupled to 3-tributylstannyl-7-trifluoromethylimidazo[1,2-α]pyrimidine (0.18 mmol) by the method of Example 32. Purification by chromatography on silica gel eluting with dichloromethane containing 3% methanol, then recrystallisation from toluene/isohexane, gave 3-[2-fluoro-5-(7-trifluoromethylimidazo[1,2-α]pyrimidin-3-yl)phenyl]isonicotinonitrile as a yellow solid: δH (400 MHz, CDCl3) 7.30 (1H, d, J 7), 7.51 (1H, t, J 9), 7.67-7.73 (3H, m), 8.13 (1H, s), 8.87 (1H, d, J 5), 8.96-8.98 (2H, m); m/z (ES+) 384 (M++H).

Provenance & Evidence