Bis(neopentyl glycolato)diboron → HCID 22329538, compound

HRID 2184053Notes

Reaction equation

HRID 2184053 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:14])=[C:6]([C:8]2[N:9]=[N:10][CH:11]=[CH:12][CH:13]=2)[CH:7]=1.[B:15]1(B2OCC(C)(C)CO2)[O:20]CC(C)(C)C[O:16]1>>[F:14][C:5]1[CH:4]=[CH:3][C:2]([B:15]([OH:20])[OH:16])=[CH:7][C:6]=1[C:8]1[N:9]=[N:10][CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 2734316Bis(neopentyl glycolato)diboronHCID 22329531HCID 22329531, compound

Product 1

HCID 22329538HCID 22329538, compound

Procedure

3-(5-Bromo-2-fluorophenyl)pyridazine (304 mg, 1.20 mmol) was reacted with bis(neopentyl glycolato)diboron (298 mg, 1.32 mmol) using the method in Example 51 to give 4-fluoro-3-(pyridazin-3-yl)phenylboronic acid as a white solid: m/z (ES+) 219 (M++H).

Sources & evidence

ORD record
ord-d1dd0f8150774cf092a8576dd72d1563
Source dataset
uspto-grants-2005_05
Patent number
US06900215B2

Reaction notes

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